Nucleotide and Serotonin Metabolism in Platelets With Defective Secondary Aggregation
نویسندگان
چکیده
منابع مشابه
Nucleotide and serotonin metabolism in platelets with defective secondary aggregation.
Ten patients with qualitative platelet defects have been investigated. All of the patients had impairment of secondary platelet aggregation induced by ADP, epinephrine, and collagen, and a defective release reaction. In seven patients from four families, the abnormality was consistent with the lack of a metabolically inert adenine nucleotide pool. Four of these patients, from two families, were...
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Platelets from a patient with a severe lifelong bleeding tendency. which later spontaneously disappeared, lacked intact thrombospondin and glycoprotein (GP) Ia. Before disappearance of the bleeding disorder, results of coagulation studies and platelet aggregation in response to adenosine diphsophate (ADP). arachidonic acid. thrombin. A231 87, epinephrine. and ristocetin were normal. In contrast...
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ژورنال
عنوان ژورنال: Blood
سال: 1974
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v44.6.789.789